[General concepts and pathogenesis of the spondyloarthropathies]
Abstract:
The spondyloarthritides are a group of interrelated diseases with a close association with the HLA-B27 antigen that share many common articular and extra-articular features. This paper summarizes the different classification criteria that are currently in use. While the exact pathogenesis of these diseases is not yet clearly elucidated, there are a number of hypotheses relating to HLA-B27, modifications of the microbiome and biomechanical stresses. This in turn leads to upregulation of various proinflammatory cytokines such as TNF-alpha, IL-17, IL-22 and IL-23, which results in further inflammation and osteoproliferation.
More Related Videos
Related Concept Videos
Atherosclerosis I: Introduction
Rheumatic Heart Disease I: Introduction
Coronary Artery Disease II: Pathophysiology
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Peripheral Artery Disease I: Introduction
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...


