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Lung embolism with liquid silicone.

M A Rodríguez1, M C Martínez, M Lopez-Artíguez

  • 1Histopathological Department, Instituto Nacional de Toxicologia, Seville, Spain.

Journal of Forensic Sciences
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Repeated injections of liquid silicone for cosmetic reasons led to a fatal lung embolism. Analysis confirmed methylsilicone in lung tissue, prompting further animal studies on its effects.

Area of Science:

  • Medical Examiner
  • Toxicology
  • Pathology

Background:

  • Liquid silicone injections are used for aesthetic purposes.
  • Complications can arise from non-medical grade silicone use.
  • Pulmonary embolism is a serious potential adverse event.

Observation:

  • A death occurred following repeated injections of liquid silicone for aesthetic reasons.
  • The injected substance was identified as methylsilicone.
  • Silicone was detected within vacuoles in lung tissue.

Findings:

  • Infrared spectrophotometry identified the injected liquid as methylsilicone.
  • Scanning electron microscopy with energy dispersive X-ray analysis (EDXA) confirmed silicone presence in lung vacuoles.
  • A study involving intravenous and subcutaneous methylsilicone injections in rats was conducted.

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Implications:

  • This case highlights the risks associated with non-medical grade liquid silicone injections.
  • Understanding silicone migration and pulmonary effects is crucial for patient safety.
  • Further research is needed to elucidate the mechanisms of silicone-induced lung injury.