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Updated: Mar 22, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Published on: April 1, 2015

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[Pre-Thrombotic (Hypercoagulable) State/Hypercoagulable Disease]

Hideo Wada

    Rinsho Byori. the Japanese Journal of Clinical Pathology
    |April 20, 2016
    PubMed

    A pre-thrombotic (hypercoagulable) state is observed in patients with thrombophilia, malignant diseases, pregnancy, auricular fibrillation, connective tissue diseases, prosthetic replacement arthroplasty, infection, or old age, and these states are also caused by dehydration, remaining in the same position for a long time, or estrogen drugs. Such patients have a high risk of developing thrombosis. The pre-thrombotic state is diagnosed or excluded by fibrin-related markers (FRMs), such as soluble fibrin (SF), fibrinogen and fibrin degradation products (FDP), and D-dimer. The cut-off values of FRMs are higher in patients with pregnancy or malignant diseases than in other patients. Patients with more than two of the eight underlying states and three causative factors for pre-thrombotic conditions or those with one of those conditions and high levels of FRMs are diagnosed as being in a prethrombotic state. These patients should receive treatment with anticoagulant therapy.

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