Related Experiment Video
Updated: Mar 22, 2026
05:31
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
1.5K
[Pregnancy-Related Venous Thromboembolism]
Rinsho Byori. the Japanese Journal of Clinical Pathology
|April 20, 2016
Summary
Pregnancy increases the risk of blood clots (venous thromboembolism or VTE) due to changes in clotting factors. Deficiencies in natural anticoagulants, particularly antithrombin, are a significant cause of VTE during pregnancy.
Area of Science:
- Hematology
- Obstetrics
- Genetics
Context:
- Pregnancy is a prothrombotic state due to altered hemostasis.
- Venous thromboembolism (VTE) is a major cause of maternal mortality.
- Congenital deficiencies in natural anticoagulants increase VTE risk.
Purpose:
- To examine hemostatic abnormalities in pregnant women with deep vein thrombosis (DVT).
- To investigate the role of congenital antithrombin (AT) and protein C (PC) deficiencies in pregnancy-related VTE.
Summary:
- 14 pregnant women with DVT were studied, alongside families with congenital AT and PC deficiencies.
- Lower AT activity and protein S (PS) levels were observed at DVT onset.
- Gene analysis identified various AT and PC mutations, including combined deficiencies.
Impact:
- Highlights the critical role of natural anticoagulant deficiencies, especially AT deficiency, in pregnancy-related VTE.
- Provides insights into specific genetic mutations predisposing to VTE in pregnant individuals.
- Underscores the need for monitoring and potential intervention in high-risk pregnancies.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
663
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
663
01:29Venous Thrombosis III: Interprofessional Care
459
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
459
01:30Venous Thrombosis IV: Nursing Management
366
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
366
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
430
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
430
01:29Pulmonary Embolism I: Introduction
1.2K
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
1.2K
01:27Pulmonary Embolism III: Nursing Management
632
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
632