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Isolation and Identification of Extravascular Immune Cells of the Heart
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Isolation and Identification of Extravascular Immune Cells of the Heart

Published on: August 23, 2018

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Decrease of circulating myeloid dendritic cells in patients with chronic heart failure

Rudin Pistulli, Nadin Hammer, Ilonka Rohm

    Acta Cardiologica
    |April 20, 2016
    PubMed

    Insights

    Circulating myeloid dendritic cells (mDCs) are reduced in chronic heart failure (CHF) patients, with lower levels indicating more severe disease. This finding highlights the role of mDCs in heart failure progression.

    Area of Science:

    • Immunology
    • Cardiology
    • Inflammation research

    Background:

    • Immunity and inflammation are crucial in chronic heart failure (CHF).
    • Dendritic cells (DCs) are key immune players, but their role in CHF is unclear.
    • This study investigates circulating DCs in compensated CHF patients.

    Purpose of the Study:

    • To examine circulating myeloid (mDCs) and plasmacytoid (pDCs) dendritic cells in patients with compensated CHF.
    • To correlate DC levels with inflammatory cytokines and heart failure severity markers.

    Main Methods:

    • Flow cytometry was used to analyze mDCs and pDCs in CHF patients (dilated cardiomyopathy [DCM] and ischemic cardiomyopathy [ICM]) and controls.
    • Levels of interleukins (IL-6, IL-10) were measured.
    • Correlations were assessed between DCs, cytokines, and heart failure parameters (NYHA class, BNP, echocardiography).

    Main Results:

    • Circulating mDCs were significantly decreased in all CHF patients compared to controls, with lower levels in DCM than ICM.
    • No significant changes were found in pDCs.
    • Reduced mDCs correlated with poorer left ventricular ejection fraction, larger LV end-diastolic diameter, and higher BNP levels in DCM patients.
    • mDCs inversely correlated with IL-6 and IL-10 in all CHF patients.

    Conclusions:

    • Blood mDCs are decreased in patients with chronic heart failure.
    • The reduction in mDCs is associated with the severity of heart failure.
    Abstract

    Keywords:
    Chronic heart failurecytokinedendritic celldilated cardiomyopathyischaemic cardiomyopathy

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