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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
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[Cerebral venous thrombosis during tuberculous meningoencephalitis]
W Guenifi1, H Boukhrissa1, A Gasmi1
1Service des maladies infectieuses, université Ferhat Abbes Sétif 1, CHU de Sétif, 19000 Sétif, Algérie.
Journal Des Maladies Vasculaires
|April 20, 2016
Summary
Tuberculosis is a rare cause of cerebral venous sinus thrombosis (CVST). This study found three cases of CVST in 61 neuro-meningeal tuberculosis patients, with favorable outcomes after treatment.
Area of Science:
- Neurology
- Infectious Diseases
- Vascular Medicine
Background:
- Cerebral venous thrombosis (CVST) is a rare condition with diverse causes.
- Infections are an uncommon etiology of CVST, accounting for less than 10% of cases.
- Tuberculosis as a cause of CVST is exceptionally rare, with limited published data.
Observation:
- A review of 61 patients with neuro-meningeal tuberculosis between 2005 and 2015 identified three young women with CVST.
- No specific clinical features were noted in these patients.
- Affected cerebral venous sinuses included the sagittal (2 cases), lateral (2 cases), and transverse (1 case).
Findings:
- All three patients with neuro-meningeal tuberculosis and CVST experienced favorable outcomes with combined anticoagulant and antituberculosis therapy.
- Cerebral venous sinus thrombosis can occur in neuro-meningeal tuberculosis without typical signs of encephalitis, hydrocephalus, tuberculoma, or ischemic stroke.
Implications:
- Clinicians should consider CVST in patients with neuro-meningeal tuberculosis presenting with neurological deficits.
- Early diagnosis and treatment of CVST in the context of tuberculosis can lead to positive patient outcomes.
- This highlights the importance of investigating CVST in neuro-meningeal tuberculosis, even in the absence of specific clinical indicators.
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