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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Updated: Mar 22, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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FDG-PET imaging in hematological malignancies.

L Valls1, C Badve1, S Avril2

  • 1Department of Radiology, University Hospitals Case Medical Center, Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH 44106, USA.

Blood Reviews
|April 20, 2016
PubMed
Summary
This summary is machine-generated.

Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is crucial for aggressive lymphomas due to high glycolytic activity. This imaging technique aids in staging, treatment monitoring, and response assessment, potentially reducing the need for biopsies.

Keywords:
FDGFLTGa-68 CXCR4Hematologic malignanciesLeukemiaLymphomaPETPET/CTPET/MRI

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Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by PET/CT
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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Aggressive lymphomas exhibit upregulated glycolytic activity, making them detectable via F-18 FDG-PET/CT.
  • Hybrid FDG-PET/CT integrates functional and morphological data, surpassing individual CT or FDG-PET imaging.
  • FDG-PET/CT is recommended for lymphoma staging, restaging, therapy monitoring, response assessment, and detecting malignant transformation.

Purpose of the Study:

  • To review the established and emerging roles of FDG-PET/CT in the management of aggressive lymphomas.
  • To highlight the utility of FDG-PET/CT in response assessment and its potential to obviate bone marrow biopsies.
  • To discuss current limitations and future directions in PET/CT imaging for lymphomas.

Main Methods:

  • Review of current literature and guidelines on FDG-PET/CT applications in lymphoma.
  • Analysis of FDG-PET/CT's performance in staging, response assessment (including Deauville Criteria), and surveillance.
  • Exploration of novel PET tracers and hybrid imaging techniques (PET/CT, PET/MRI).

Main Results:

  • FDG-PET/CT is effective for staging, monitoring, and assessing treatment response in FDG-avid lymphomas.
  • It can potentially replace bone marrow biopsy in Hodgkin lymphoma and diffuse large B-cell lymphoma.
  • CT-based assessment remains crucial for lymphomas with low or variable FDG avidity.

Conclusions:

  • FDG-PET/CT is a valuable tool in lymphoma management, offering comprehensive information for treatment decisions.
  • While promising for predicting therapeutic response, its use should be confined to clinical trials.
  • Surveillance FDG-PET/CT post-remission is discouraged due to high false-positive rates; future research focuses on new tracers and technologies.