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Leptin and Atopic Dermatitis in Korean Elementary School Children
SungChul Seo1, Won Suck Yoon2, Yunjung Cho3
1Environmental Health Center, Korea University Anam Hospital, Seoul, Korea AND Allergy Immunology Center, Korea University, Seoul, Korea.
Iranian Journal of Allergy, Asthma, and Immunology
|April 20, 2016
Summary
Serum leptin levels were higher in children with non-atopic dermatitis or mild-to-moderate atopic dermatitis (AD). This suggests leptin may play a role in AD, but not necessarily IgE-mediated inflammation.
Area of Science:
- Pediatric Dermatology
- Immunology
- Endocrinology
Background:
- Atopic dermatitis (AD) and obesity are rising in Korean children.
- Leptin, a hormone from fat cells, may influence immunity, but its role in AD is unclear.
Purpose of the Study:
- To investigate the relationship between serum leptin levels and atopic dermatitis in Korean school children.
- To explore if leptin levels differ between atopic and non-atopic AD, and by AD severity.
Main Methods:
- A survey identified 227 children with AD from 2,109 students.
- Ninety AD children (6-12 years) underwent SCORAD, skin prick tests, and blood tests (IgE, eosinophils, ECP, lipids, leptin).
- Atopic AD was defined by positive allergen skin prick tests.
Main Results:
- Serum leptin levels were significantly higher in non-atopic AD than atopic AD (p=0.045).
- Leptin levels were higher in mild-to-moderate AD compared to severe AD (p=0.028).
- No significant differences were found in age, BMI, feeding, delivery mode, atopy prevalence, or lipid profiles between atopic and non-atopic AD.
Conclusions:
- Serum leptin levels are elevated in non-atopic AD and mild-to-moderate AD.
- Leptin's association with AD may differ based on atopy status and disease severity.
- Leptin does not appear to be linked to IgE-mediated inflammation in AD.
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