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Updated: Mar 22, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
A systematic review of interventions to improve adherence to melanoma preventive behaviors for individuals at
Yelena P Wu1, Lisa G Aspinwall2, Bridgid M Conn3
1Division of Public Health, Department of Family and Preventive Medicine, University of Utah, USA; Huntsman Cancer Institute, USA.
Background And Objectives:
To examine the effectiveness of behavioral interventions for melanoma prevention targeted to individuals at elevated risk due to personal and/or family history.
Methods:
Through literature searches in 5 search databases (through July 2014), 20 articles describing 14 unique interventions focused on melanoma prevention among individuals at elevated risk for the disease were identified. Interventions targeting only patients undergoing active treatment for melanoma were excluded.
Results:
The average study quality was moderate. The majority of interventions (6 out of 9, 66% of studies) led to improvements in one or more photoprotective behaviors, particularly for improvements in use of protective clothing (3 out of 5, 60% of studies), and frequency and/or thoroughness of skin self-examinations (9 out of 12, 75%). Fewer interventions (5 out of 14, 36%) targeted uptake of total body skin examinations (60% led to improvements). Also, fewer interventions targeted all three preventive behaviors (5 out of 14, 36%).
Conclusions:
Findings suggest that future interventions should aim to improve adherence across multiple preventive behaviors, over a longer time period (past 8months post-intervention), and target high-risk children. Studies should include adequate sample sizes to investigate moderators and mediators of intervention effectiveness. Interventions may be strengthened by new techniques, such as incorporating family members (e.g., to improve thoroughness of skin self-examinations) and eHealth technology.
Insights
Behavioral interventions show promise for melanoma prevention in high-risk individuals, improving protective behaviors like clothing use and skin self-exams. Future efforts should focus on sustained adherence and broader behavior targeting.
Area of Science:
- Dermatology
- Public Health
- Behavioral Science
Background:
- Individuals with a personal or family history of melanoma are at elevated risk.
- Effective melanoma prevention strategies are crucial for this high-risk population.
Purpose of the Study:
- To evaluate the efficacy of behavioral interventions designed for melanoma prevention.
- To identify interventions targeting individuals at high risk due to personal or family history.
Main Methods:
- A comprehensive literature search was conducted across five databases up to July 2014.
- Twenty articles detailing 14 unique interventions for high-risk melanoma prevention were identified and analyzed.
- Studies focused on active melanoma treatment patients were excluded.
Main Results:
- The average quality of included studies was moderate.
- Most interventions (66%) improved at least one photoprotective behavior, notably protective clothing use (60%) and skin self-examination frequency/thoroughness (75%).
- Fewer interventions (36%) targeted total body skin examinations, and only 36% addressed all three key preventive behaviors.
Conclusions:
- Future interventions should promote adherence to multiple preventive behaviors over extended periods.
- Targeting high-risk children and incorporating family members or eHealth technology may enhance intervention effectiveness.
- Further research needs adequate sample sizes to explore intervention moderators and mediators.
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