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Updated: Mar 22, 2026
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
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Is There a Genetic Correlation between Multiple Sclerosis and Cerebral Aneurysms?
Fatimah M Albrekkan1, Suha Bachir2, Mouhammed A Jumaa3
1Division of Neurosurgery, Department of Surgery, University of Toledo Medical Center, Toledo, Ohio, USA; Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia.
World Neurosurgery
|April 20, 2016
Summary
This study suggests a potential genetic link between multiple sclerosis (MS) and cerebral aneurysms (CAs). The TNFRSF1A gene may play a role in the development of both conditions.
Area of Science:
- Neuroimmunology
- Vascular Neurology
Background:
- Multiple sclerosis (MS) is an autoimmune neurodegenerative disease with uncertain pathogenesis, influenced by genetic and environmental factors.
- Cerebral aneurysms (CAs) are dangerous bulges in brain arteries, and a potential link with MS has been hypothesized.
- Previous research has not established an association between MS and CA development.
Observation:
- This report details two cases of MS patients who underwent middle cerebral artery aneurysm clipping.
- The aneurysms were incidentally discovered during magnetic resonance imaging.
- The study aimed to explore potential genetic correlations in the pathogenesis of MS and CA.
Findings:
- A possible genetic association between MS and CAs is suggested.
- The TNFRSF1A gene shows the strongest evidence of association.
- TNFRSF1A is a proinflammatory gene involved in MAPK and NF-Kappa B pathways, implicated in MS and elevated in CAs.
Implications:
- This finding may open new avenues for understanding the shared genetic underpinnings of MS and CAs.
- Further research into the TNFRSF1A gene could elucidate disease mechanisms and inform therapeutic strategies.
- Identifying shared risk factors could lead to improved diagnostic and preventative approaches for patients with MS or CA.
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