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Updated: Mar 22, 2026
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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Development and characterization of fast-dissolving tablet formulations of glyburide based on solid
Marzia Cirri1, Alessandra Roghi2, Maurizio Valleri3
1Chemistry Dept., School of Sciences of Human Health, University of Florence, via U. Schiff 6, Sesto Fiorentino 50019, Florence, Italy.
Summary
This study developed fast-dissolving glyburide tablets using Solid-Self MicroEmulsifying Drug Delivery Systems (S-SMEDDS). The novel S-SMEDDS approach significantly improved drug dissolution properties compared to micronized glyburide.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Formulation Development
Background:
- Glyburide dissolution is critical for its therapeutic efficacy.
- Traditional formulations may exhibit suboptimal drug release profiles.
- Self-MicroEmulsifying Drug Delivery Systems (SMEDDS) offer potential for enhanced drug solubility and bioavailability.
Purpose of the Study:
- To develop effective fast-dissolving glyburide tablet formulations.
- To investigate the efficacy of the Solid-Self MicroEmulsifying Drug Delivery System (S-SMEDDS) approach for glyburide.
- To enhance the dissolution and technological properties of glyburide tablets.
Main Methods:
- Screening of oils, surfactants, and co-surfactants for liquid SMEDDS formulation.
- Construction of pseudo-ternary phase diagrams to optimize SMEDDS components.
- Conversion of liquid SMEDDS to S-SMEDDS by adsorption onto Neusilin.
- Comprehensive characterization of S-SMEDDS and final tablets (solid-state, morphology, dissolution, particle size).
- Evaluation of drug dissolution profiles using ratio and similarity factors.
Main Results:
- Optimized liquid SMEDDS formulations were developed using Capryol 90, Tween 20, and Glycofurol or Transcutol.
- S-SMEDDS formulations were successfully prepared and characterized, with the 1:1 S-SMEDDS/Glycofurol/Neusilin showing optimal performance.
- Developed fast-dissolving tablets demonstrated complete glyburide dissolution within 10-15 minutes.
- Dissolution profiles of S-SMEDDS tablets were significantly different and superior to those of micronized glyburide formulations.
Conclusions:
- The S-SMEDDS approach is effective for developing fast-dissolving glyburide tablets.
- This method significantly enhances drug dissolution properties and technological characteristics.
- The developed S-SMEDDS tablets offer a promising alternative for improved glyburide delivery.
Keywords:
Croscarmellose (PubChem CID: 24748)Difference factorFast dissolving tabletsGlyburideGlyburide (PubChem CID: 3488)Glycofurol (PubChem CID: 8200)Kollidon (PubChem CID: 6917)Neusilin (PubChem CID: 3084116)Pair-wise procedureSimilarity factorSolid Self-MicroEmulsifying Drug Delivery SystemSolid-SMEDDSTranscutol (PubChem CID: 8146)Tween 20 (PubChem CID: 443314)
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