Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.8K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.8K
Overview of Exosomes01:36

Overview of Exosomes

3.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.9K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

8.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic inhibition of glutamate-cysteine ligase increases dendritic cell-mediated antitumor immunity in melanoma.

Journal for immunotherapy of cancer·2026
Same author

Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner.

Frontiers in oncology·2025
Same author

Erratum: U1 Adaptor Oligonucleotides Targeting <i>BCL2</i> and <i>GRM1</i> Suppress Growth of Human Melanoma Xenografts <i>In Vivo</i>.

Molecular therapy. Nucleic acids·2025
Same author

Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner.

bioRxiv : the preprint server for biology·2024
Same author

An In Vivo Study of LNS8801, a GPER Agonist, in a Spontaneous Melanoma-Prone Mouse Model, TGS.

Pigment cell & melanoma research·2024
Same author

Current frameworks for environmental and health assessment of hydrocarbon streams and products are flexible and ready for alternative non crude oil-based feeds.

Toxicology research·2024

Related Experiment Video

Updated: Mar 22, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

10.7K

Exosomes: The Link between GPCR Activation and Metastatic Potential?

Allison L Isola1, Suzie Chen2

  • 1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers the State UniversityPiscataway, NJ, USA; Joint Graduate Program in Toxicology, Environmental and Occupational Health Sciences Institute, Rutgers the State UniversityPiscataway, NJ, USA.

Frontiers in Genetics
|April 20, 2016
PubMed
Summary

G-Protein Coupled Receptors (GPCRs) signaling may activate proteins that control exosome release. This links GPCRs to tumor cell communication and metastasis preparation.

Keywords:
GPCRcancerexosomemGluRpre-metastatic niche

More Related Videos

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K
Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

21.0K

Related Experiment Videos

Last Updated: Mar 22, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

10.7K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K
Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

21.0K

Area of Science:

  • Cellular Biology
  • Oncology
  • Molecular Signaling

Background:

  • G-Protein Coupled Receptors (GPCRs) regulate vital cellular functions, and their dysregulation is linked to cancer.
  • Metastasis, the spread of cancer cells, is a major cause of cancer mortality.
  • Cellular communication, potentially via nanovesicles called exosomes, is crucial in early metastasis.

Purpose of the Study:

  • To investigate if GPCR signaling cascades can activate proteins involved in exosome production and release.
  • To establish a link between GPCRs and tumor cell exosome-mediated communication in metastasis.

Main Methods:

  • Review of existing literature on GPCR signaling, exosome biology, and cancer metastasis.
  • Analysis of proposed molecular mechanisms connecting GPCR pathways to exosome biogenesis and release.

Main Results:

  • Cancer cells release more exosomes than normal cells, suggesting altered exosome regulation in tumors.
  • Proteins controlling multivesicular body function regulate exosome production and release.
  • GPCR signaling cascades are hypothesized to be upstream activators of these exosome-related proteins.

Conclusions:

  • GPCRs may play a role in regulating tumor-derived exosome release.
  • This connection provides a potential link between a key cell surface receptor class and the metastatic process.
  • Targeting GPCRs could offer novel strategies to inhibit cancer cell communication and metastasis.