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Updated: Mar 22, 2026

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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The Chicago Thoracic Oncology Database Consortium: A Multisite Database Initiative.

Brian Won1, George B Carey2, Yi-Hung Carol Tan1

  • 1Section of Hematology/Oncology, The University of Chicago Medicine.

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|April 20, 2016
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Summary

The Chicago Thoracic Oncology Database Consortium (CTODC) successfully pooled lung cancer patient data, showing EGFR-mutated patients had longer erlotinib treatment and survival. This demonstrates effective data sharing for future research.

Keywords:
bioinformaticsdatabaselung cancer

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Area of Science:

  • Biomedical Informatics
  • Oncology Research
  • Translational Medicine

Background:

  • Increasing clinical data necessitates robust informatics infrastructures for efficient data pooling and sharing among researchers.
  • The Chicago Thoracic Oncology Database Consortium (CTODC) was established to standardize data collection and facilitate collaborative research.
  • A proof-of-principle investigation was conducted using the CTODC to assess its utility in handling lung cancer patient data.

Purpose of the Study:

  • To evaluate the effectiveness of the Chicago Thoracic Oncology Database Consortium (CTODC) in standardizing and sharing clinical data.
  • To demonstrate the capability of the CTODC infrastructure through a study on lung cancer patients treated with erlotinib.
  • To establish a foundation for future collaborative research and database development within the consortium.

Main Methods:

  • Implemented databases including Thoracic Oncology Program Database Project (TOPDP) in Microsoft Access, Thoracic Oncology Research Program (TORP) in Velos, and TORP REDCap.
  • Developed Standard Operating Procedures (SOPs) for database construction and utilization, making them freely available to other institutions.
  • Identified a cohort of 373 lung cancer patients who received erlotinib for analysis.

Main Results:

  • Successfully collected and integrated data from multiple institutions within the CTODC.
  • Analyzed 70 patients for EGFR mutation status, with 55 testing positive.
  • Demonstrated that EGFR-mutated patients had longer duration of erlotinib treatment and improved overall survival compared to EGFR wild-type patients.

Conclusions:

  • The CTODC successfully facilitated data collection and yielded valuable insights into erlotinib treatment outcomes in lung cancer patients.
  • Identified challenges such as data transfer difficulties and potential data duplication, which can be mitigated through enhanced inter-institutional communication.
  • The study validates the CTODC's potential as a platform for future collaborative research and the development of more streamlined databases.