Related Experiment Video

Updated: Mar 22, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

7.5K

Small Non-coding RNAs Associated with Viral Infectious Diseases of Veterinary Importance: Potential Clinical

Mohamed Samir1, Frank Pessler2

  • 1TWINCORE Center for Experimental and Clinical Infection Research, Hannover, Germany; Zoonoses Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Frontiers in Veterinary Science
|April 20, 2016
PubMed

Insights

MicroRNAs (miRNAs) show promise for diagnosing and treating animal viral diseases. This review explores preclinical studies and challenges for veterinary clinical applications of these small non-coding RNAs.

Area of Science:

  • Veterinary Medicine
  • Molecular Biology
  • Virology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNA molecules regulating gene expression.
  • miRNAs are stable, conserved, and ubiquitous, suggesting clinical potential.
  • miRNA applications are established in human viral diseases but emerging in veterinary medicine.

Purpose of the Study:

  • To review preclinical studies on using small non-coding RNAs (sncRNAs) against viral diseases in animals.
  • To discuss the clinical translation of sncRNA-based strategies for veterinary applications.
  • To highlight the diagnostic, prognostic, and therapeutic potential of miRNAs in veterinary virology.

Main Methods:

  • Literature review of preclinical studies on sncRNAs and animal viral diseases.
  • Analysis of current research on miRNA-based diagnostics and therapeutics.
  • Discussion of challenges and opportunities for clinical implementation.

Main Results:

  • Preclinical studies demonstrate the potential of sncRNAs to combat viral infections in pets and farm animals.
  • miRNAs can serve as biomarkers for disease diagnosis and prognosis.
  • Dysregulated miRNAs present therapeutic targets and tools for developing disease-resistant livestock.

Conclusions:

  • Small non-coding RNAs, particularly miRNAs, offer significant potential for veterinary clinical applications.
  • Further research and development are needed to overcome challenges in translating these findings to the clinic.
  • sncRNAs could revolutionize the diagnosis, treatment, and prevention of viral diseases in animals.
Keywords:
animal virusesanimalsbiomarkersclinical applicationinfectious diseasesmiRNAsmall non-coding RNAsveterinary science

More Related Videos

Rescue of Recombinant Newcastle Disease Virus from cDNA10:55

Rescue of Recombinant Newcastle Disease Virus from cDNA

Published on: October 11, 2013

20.5K
Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

Published on: April 4, 2019

17.5K

Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
19.0K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.6K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.2K
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
4
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.5K
Subviral Agents01:29

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
724