Non-Antibiotic Prophylaxis for Urinary Tract Infections
Mariëlle Beerepoot1, Suzanne Geerlings2
1Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. M.A.Beerepoot@amc.uva.nl.
Pathogens (Basel, Switzerland)
|April 20, 2016
Summary
Non-antibiotic strategies show promise for preventing recurrent urinary tract infections (UTIs). Probiotics like Lactobacillus strains and cranberry products may reduce UTI occurrences, offering alternatives to antibiotics.
Area of Science:
- Urology
- Infectious Diseases
- Microbiology
Background:
- Antimicrobial resistance necessitates exploring non-antibiotic prophylaxis for recurrent urinary tract infections (UTIs).
- UTI pathogenesis involves uropathogen colonization and adherence to uroepithelial cells.
- Estrogen therapy has shown efficacy in reducing UTIs in postmenopausal women.
Purpose of the Study:
- To review non-antibiotic strategies for preventing recurrent UTIs.
- To evaluate the effectiveness of probiotics, cranberry products, and other interventions.
Main Methods:
- Literature review of studies on non-antibiotic UTI prophylaxis.
- Analysis of clinical trial data for various interventions.
Main Results:
- Vaginal estrogens restore lactobacilli flora and reduce UTIs in postmenopausal women.
- Specific Lactobacillus strains (e.g., L. crispatus, L. rhamnosus GR-1, L. reuteri RC-14) show potential for UTI prevention.
- Cranberry products demonstrate moderate effectiveness in reducing UTI recurrences in premenopausal women.
- Ascorbic acid and OM-89 vaccine were not found effective for UTI prevention.
Conclusions:
- Certain probiotic strains and cranberry products offer promising non-antibiotic options for recurrent UTI prevention.
- Further research is needed to determine optimal dosages and specific applications for these interventions.
Related Concept Videos
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
392
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
392
01:17Urinary Tract Infection IV: Nursing Management
581
In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
581
01:26Urinary Tract Infection I: Introduction
994
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
994
01:25Urinary Tract Infection II: Pathophysiology
1.1K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.1K
01:26Urine Studies II: Urine Culture and Sensitivity Test
2.0K
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
2.0K
01:28Microbiota of the Urogenital Tract
16
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
16