Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

6.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
6.8K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

326
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
326
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K
Development of Human Microbiota01:30

Development of Human Microbiota

9
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
9
Signs of Puberty01:27

Signs of Puberty

1.9K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.9K
Body Water Content and Fluid Compartments01:19

Body Water Content and Fluid Compartments

5.0K
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction: Interventions against disability in frail older adults: Lessons learned from clinical trials.

The journal of nutrition, health & aging·2026
Same author

Corrigendum to "Current and investigational medications for the treatment of sarcopenia" [Metabolism 2023;149:155597].

Metabolism: clinical and experimental·2026
Same author

Challenges and opportunities for novel combination therapies in Alzheimer's disease: a report from the EU/US CTAD Task Force.

The journal of prevention of Alzheimer's disease·2025
Same author

Exercise interventions to improve physical frailty and physical frailty components in older adults with hypertension: A systematic review.

Ageing research reviews·2025
Same author

Editorial: ICOPE Healthy Longevity Integrative Preventive Care, Alzheimer's Disease Prevention and Early Diagnosis.

The journal of prevention of Alzheimer's disease·2024
Same author

Clinical Meaningfulness in Alzheimer's Disease Clinical Trials. A Report from the EU-US CTAD Task Force.

The journal of prevention of Alzheimer's disease·2024
Same journal

From health literacy to capacity preservation: advancing the next step in midlife frailty prevention.

The Journal of frailty & aging·2026
Same journal

An OLD DOG teaching us new tricks in ageing biology.

The Journal of frailty & aging·2026
Same journal

"This has no flavor": balancing nutrition, taste, and salt restriction in geriatric care units.

The Journal of frailty & aging·2026
Same journal

Screening of intrinsic capacity impairment in community-dwelling older adults in Cameroon: A national cross-sectional study.

The Journal of frailty & aging·2026
Same journal

Comparing two methods to quantify physical resilience.

The Journal of frailty & aging·2026
Same journal

Phenotypes of frailty and their mortality and disability implications.

The Journal of frailty & aging·2026
See all related articles

Related Experiment Video

Updated: Mar 22, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

830

Gender Specific Associations between Frailty and Body Composition.

D L Waters1, G Abellan van Kan, M Cesari

  • 1Debra Waters, PhD, University of Otago, Dunedin School of Medicine, Department of Preventive and Social Medicine, PO Box 913, Dunedin, New Zealand 9054, Tel 64 3 479 7222, Fax 64 3 479 7298, Email debra.waters@otago.ac.nz.

The Journal of Frailty & Aging
|April 20, 2016
PubMed
Summary
This summary is machine-generated.

Frailty in older adults is linked to body composition differently in men and women. Appendicular skeletal muscle mass (ASM) is key for men, while body fat percentage is significant for women, independent of age.

More Related Videos

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.5K

Related Experiment Videos

Last Updated: Mar 22, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

830
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.5K

Area of Science:

  • Geriatric Medicine
  • Body Composition Analysis
  • Aging Research

Background:

  • Frailty is a common geriatric syndrome with poorly understood links to body composition.
  • Understanding these links is crucial for targeted interventions in aging populations.

Purpose of the Study:

  • To investigate the relationship between body composition and frailty in community-dwelling older adults.
  • To determine if these relationships differ between genders.

Main Methods:

  • Cross-sectional study of 120 older adults (70 women, 50 men).
  • Frailty assessed using Fried's criteria.
  • Body composition measured by dual-energy x-ray absorptiometry, including appendicular skeletal muscle mass (ASM) and body fat percentage.
  • Gender-stratified multiple and logistic regression analyses were performed.

Main Results:

  • Frailty prevalence was higher in women (67.1%) than men (46%).
  • Low muscle mass (ASM/ht2) was more common in men (40%), while obesity was more prevalent in women (58.6%).
  • Appendicular skeletal muscle mass (ASM/ht2) was a significant factor for frailty in men (p<0.001), while body fat percentage was significant for women (p=0.02), independent of age.

Conclusions:

  • In older men, frailty is significantly associated with appendicular skeletal muscle mass (ASM/ht2).
  • In older women, frailty is significantly associated with body fat percentage.
  • These gender-specific associations highlight the importance of tailored approaches to managing frailty in aging populations, considering sarcopenia and obesity prevalence.