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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Insights into next developments in advanced gastric cancer
Radka Obermannová1, Florian Lordick
1aClinic of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk University, Brno, Czech Republic bUniversity Cancer Center Leipzig (UCCL), University Hospital Leipzig, Leipzig, Germany.
Novel biology-based treatments for advanced gastric cancer are emerging, including anti-HER2 therapies and angiogenesis inhibitors like ramucirumab. Challenges remain in understanding resistance and selecting patients, despite ongoing research into biomarkers and immunotherapy.
Area of Science:
- Oncology
- Gastroenterology
- Molecular Biology
Background:
- Gastric cancer treatment is evolving with new molecular classifications.
- Understanding tumor heterogeneity is crucial for personalized medicine.
Purpose of the Study:
- To review novel biology-based treatment approaches for advanced gastric cancer.
- To highlight recent advancements in drug development and patient stratification.
Main Methods:
- Review of translational and clinical research articles.
- Analysis of congress presentations on gastric cancer therapies.
Main Results:
- A new molecular classification aids drug development and patient selection.
- Anti-HER2 therapy shows promise in perioperative settings.
- Ramucirumab improves survival in second-line treatment, but biomarkers are needed.
- Immune checkpoint blockade and cancer stemness targets are emerging strategies.
Conclusions:
- Promising biology-based strategies are developing for advanced gastric cancer.
- Tumor heterogeneity presents a significant challenge to targeted and personalized treatments.
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