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Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Cross-linking for microbial keratitis.

Tommy C Y Chan¹, Tushar Agarwal, Rasik B Vajpayee

¹aDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong bHong Kong Eye Hospital, Mongkok, Kowloon, Hong Kong SAR, China cDr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India dVision Eye Institute, Royal Victorian Eye and Ear Hospital, North West Academic Centre eCentre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.

Current Opinion in Ophthalmology

|April 20, 2016

Summary

This summary is machine-generated.

Corneal collagen cross-linking (CXL) shows promise as an add-on treatment for mild to moderate bacterial keratitis. Its effectiveness in fungal and amoebic keratitis requires further investigation, with individualized treatment plans being essential.

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Area of Science:

Ophthalmology
Microbiology
Biotechnology

Background:

Microbial keratitis is a significant cause of vision loss.
Standard antibiotic treatment faces challenges including resistance and intensive regimens.
Corneal collagen cross-linking (CXL) is emerging as a potential adjunctive therapy.

Purpose of the Study:

To review the role of CXL as an adjunctive therapy for microbial keratitis.
To evaluate the impact of CXL on disease duration, transplantation rates, visual outcomes, and antibiotic resistance.
To assess the current evidence for CXL in bacterial, fungal, and amoebic keratitis.

Main Methods:

Review of existing literature on CXL in microbial keratitis.
Analysis of reported outcomes in bacterial, fungal, and amoebic keratitis cases.
Discussion of safety and efficacy debates, particularly in early-stage disease.

Main Results:

CXL has been applied to bacterial, fungal, and amoebic keratitis with variable results.
Evidence supporting CXL's efficacy is largely anecdotal.
Safety and efficacy, especially in early disease stages, remain under debate.

Conclusions:

CXL shows potential as an adjunctive treatment for select mild to moderate bacterial keratitis cases.
Efficacy in fungal and amoebic keratitis is uncertain.
Individualized treatment protocols are necessary, and further randomized trials are needed.