Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

690
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
690
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
Antifungal Agents01:15

Antifungal Agents

20
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
20
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

2.0K
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the disconnect: A pilot study of public perception versus reality of corneal donation in India.

Indian journal of ophthalmology·2026
Same author

Multiscale Biophysical Characterization of Ultra-Short Peptide Hydrogels.

Chembiochem : a European journal of chemical biology·2026
Same author

Retraction notice to "Corrigendum to 'Chitosan-poly(lactide-co-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial keratitis'" [Carbohydrate Polymers 367 (2025) 123953].

Carbohydrate polymers·2026
Same author

Retraction notice to "Chitosan-poly(lactide-co-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial keratitis" [Carbohydrate Polymers 312 (2023) 120822].

Carbohydrate polymers·2026
Same author

Novel Inositol Acyltransferase (Gwt1) Inhibitor for Fungal Keratitis Treatment: Evaluation of In Vitro and In Vivo Efficacy and Safety.

Investigative ophthalmology & visual science·2026
Same author

Genomic insights into antimicrobial resistance in ocular pathogens from India.

Communications biology·2026

Related Experiment Video

Updated: Mar 22, 2026

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K

Update on fungal keratitis.

Prashant Garg1, Aravind Roy, Sanhita Roy

  • 1aTej Kohli Cornea Institute, KAR campus, L. V. Prasad Eye Institute, Hyderabad bTej Kohli Cornea Institute, KVC campus, L. V. Prasad Eye Institute, Vijayawada cBrien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Andhra Pradesh, India.

Current Opinion in Ophthalmology
|April 20, 2016
PubMed
Summary

Recent advancements in mycotic keratitis research emphasize molecular methods for accurate fungal identification and improved diagnosis. New drug delivery systems and therapies show promise for better treatment outcomes.

More Related Videos

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

2.0K
Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings
04:00

Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings

Published on: August 2, 2024

3.5K

Related Experiment Videos

Last Updated: Mar 22, 2026

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

2.0K
Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings
04:00

Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings

Published on: August 2, 2024

3.5K

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Mycotic keratitis is a serious eye infection often caused by fungi.
  • Accurate and timely diagnosis is crucial for effective treatment and preventing vision loss.

Purpose of the Study:

  • To review seminal research in mycotic keratitis published between July 2014 and December 2015.
  • To highlight advancements in diagnosis, understanding host responses, and therapeutic strategies.

Main Methods:

  • Literature review of recent publications on mycotic keratitis.
  • Analysis of studies employing molecular methods for fungal identification.
  • Evaluation of research on in-vitro susceptibility testing and novel therapeutic approaches.

Main Results:

  • Molecular methods are essential for precise fungal identification to species/subspecies level, aiding in diagnosing difficult cases like Pythium keratitis.
  • In-vitro susceptibility testing shows a stronger correlation with clinical outcomes.
  • Research is progressing in understanding host-pathogen interactions and developing advanced drug formulations for better pharmacokinetics and bioavailability.
  • Corneal collagen cross-linking and intracameral/stromal antifungal injections are emerging as promising clinical interventions.

Conclusions:

  • The field of mycotic keratitis is experiencing significant positive developments.
  • Molecular diagnostics will enhance diagnostic accuracy and clinico-therapeutic correlations.
  • Novel drug delivery systems with improved pharmacokinetic profiles are anticipated, offering better treatment options for patients.