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Physical characterization of the methanol solvate of urapidil
S A Botha1, M R Caira, J K Guillory
1Research Institute for Industrial Pharmacy, Potchefstroom University for C.H.E., South Africa.
Journal of Pharmaceutical Sciences
|January 1, 1989
Abstract:
The methanol solvate of urapidil was prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rate, and solution calorimetry. The stoichiometry of the urapidil:methanol solvate was found to be 1:1. The crystal and molecular structures were determined from three-dimensional X-ray data. The stability of the solvate under different storage conditions was also determined.