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Evolution of Ceftaroline-Resistant Mrsa in a Child with Cystic Fibrosis Following Repeated Antibiotic Exposure
Christopher R Cannavino1, Rodrigo E Mendes, Helio S Sader
1From the *Division of Infectious Diseases, Department of Pediatrics, University of California at San Diego and Rady Children's Hospital San Diego, San Diego, California; †JMI Laboratories, North Liberty, Iowa; ‡Cerexa, Inc., Oakland, California; and §Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California.
Abstract:
Ceftaroline is the first β-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe a ceftaroline-resistant MRSA strain, isolated from a girl with cystic fibrosis after 22 ceftaroline treatment courses. MRSA genome sequencing documented a Tyr446Asn alteration in penicillin binding protein 2 that appeared responsible for resistance. Noncompartmental ceftaroline pharmacokinetic evaluation in our patient documented increased clearance and volume of distribution compared with adults.
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