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Design of a Physical Activity Program to Prevent Functional Decline in Onco-Geriatric Patients (CAPADOGE):
J Durrieu1, A Doussau, A Rieger
1Isabelle Bourdel-Marchasson, Département de gériatrie, Hôpital Xavier Arnozan, Centre Henri Choussat, Avenue du Haut-Lévêque, 33604 Pessac cedex, France. Phone: (+33) 557 65 65 71, Fax: (+33) 557 65 65 60,
The Journal of Frailty & Aging
|April 20, 2016
Summary
Adapted physical activity phone advice can help older cancer patients maintain autonomy and limit frailty. This study explored its efficacy over one year, offering personalized exercise guidance.
Area of Science:
- Gerontology and Oncology
- Exercise Physiology
- Public Health Interventions
Background:
- Cancer and its treatments disproportionately affect older adults, increasing frailty.
- Frailty in older cancer patients is characterized by exhaustion, weight loss, muscle weakness, and reduced mobility.
- Cancer-induced frailty significantly impacts patient autonomy and quality of life.
Purpose of the Study:
- To assess the effectiveness of telephone-delivered adapted physical activity advice in preventing cancer-related loss of autonomy.
- To evaluate the intervention's impact on mitigating the development of the frailty phenotype in older cancer patients.
- To explore the potential of personalized exercise guidance to improve functional outcomes and quality of life during cancer treatment.
Main Methods:
- A multicenter randomized controlled trial involving 400 patients over 70 years undergoing curative cancer treatment.
- Intervention group received personalized phone-based physical activity advice (strength, aerobic, balance, flexibility) twice monthly for six months, then monthly for one year.
- Comparison group received usual care, both supplemented with National Nutritional Health Program (PNNS) booklet advice.
Main Results:
- The primary outcome measured was the change in Short Physical Performance Battery (SPPB) score at one year.
- Secondary outcomes included quality of life, hospitalization rates, institutionalization, mortality, and frailty phenotype development (Fried phenotype) at one and two years.
- Functional, cognitive, and clinical data were collected at baseline and at multiple follow-up points up to 24 months.
Conclusions:
- This trial will yield crucial data on the impact of exercise advice interventions for older cancer patients.
- The study will elucidate the effects on functional and cognitive trajectories and overall quality of life.
- The potential of these interventions to minimize frailty phenotype development in this vulnerable population will be investigated.
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