Related Experiment Video
Updated: Mar 22, 2026
08:24
Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
20.7K
[Bacterial Translocation from Intestine: Microbiological, Immunological and Pathophysiological Aspects]
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|April 21, 2016
Summary
Bacterial translocation (BT) is a natural process in newborns and a pathological factor in immunodeficiency. Understanding gut barrier function is key to managing infections and inflammatory diseases.
Area of Science:
- Microbiology
- Immunology
- Pathophysiology
Context:
- Bacterial translocation (BT) is a physiological process in newborns, crucial for establishing gut microbiota.
- In immunocompromised individuals, BT can be a critical factor in infection and sepsis.
- Host defense relies on gut microbiota, immune mechanisms, and barrier integrity.
Purpose:
- To explore the dual role of bacterial translocation in health and disease.
- To elucidate the mechanisms underlying intestinal barrier function and dysfunction.
- To highlight the significance of host-microbiome interactions in immune responses.
Summary:
- BT involves the passage of bacteria across the intestinal barrier, influenced by microbiota, host immunity, and barrier integrity.
- Dysfunction of the intestinal barrier, exacerbated by ischemia and inflammation, increases BT risk.
- Host defense mechanisms, including phagocytosis and immune signaling, counteract BT, with outcomes shaped by host-microbiome genomic interactions.
Impact:
- BT research offers insights into inflammatory diseases, potentially unifying their origin.
- Understanding maternal microbiota's role in infant immunity and BT is crucial.
- Further research using biomodels is needed to fully comprehend intestinal barrier dynamics.
More Related Videos
07:34Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
3.3K
06:57Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
9.7K
Related Concept Videos
01:26Bacterial Translocation and Protein Secretion
976
Bacterial protein secretion involves translocation systems to ensure proteins reach their designated locations, including the plasma membrane, periplasm, outer membrane, or the external environment. These translocation systems are vital for bacterial physiology, supporting processes like membrane assembly, enzymatic activity in the periplasm, and interactions with the external environment. The division of labor between Sec and Tat pathways ensures efficiency in handling proteins with diverse...
976
01:25Colonisation of Pathogens
12
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
12
01:18Bacterial Gastroenteritis
10
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
10
01:25Urinary Tract Infection II: Pathophysiology
1.1K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.1K
01:16Transduction
2.5K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
2.5K
01:18Functions of the Gut Microbiota
2
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
2