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Related Experiment Videos

Marathon running and immunity to atherosclerosis.

T J Bassler

    Annals of the New York Academy of Sciences
    |January 1, 1977
    PubMed
    Summary

    Marathon runners show no fatal atherosclerotic cardiovascular disease (ASCVD), but this may be due to multiple lifestyle factors, not just exercise alone. Further research is needed to determine the specific protective elements.

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    Area of Science:

    • Exercise physiology
    • Cardiovascular health
    • Nutritional science

    Background:

    • Investigating the health outcomes of endurance athletes, specifically marathon runners (42-km men).
    • Examining the potential protective effects of intense physical activity against atherosclerotic cardiovascular disease (ASCVD).

    Observation:

    • Marathon runners exhibit a notable absence of fatal ASCVD.
    • The ability to complete a 42-km run is influenced by multiple factors including exercise, diet, and tobacco avoidance.
    • Some athletes report benefits from high-dose ascorbic acid intake and specific dietary patterns (high polyunsaturated/saturated fat ratio).
    • Smoking is exceptionally rare in this cohort, suggesting a potential link to adverse cardiovascular effects.

    Findings:

    • While no deaths from coronary atherosclerosis have been recorded in marathon finishers in this interim report, attributing this solely to exercise is not supported.
    • Animal studies suggest high ascorbic acid intake may promote collagen synthesis.
    • A macrobiotic diet with a high P/S ratio is common among these athletes and impacts training capacity.
    • Tobacco smoke may contain agents that promote the formation of toxic lipid oxides from linoleic acid.

    Implications:

    • Marathon runners may be developing long-term protection against ASCVD, similar to heavily active longshoremen.
    • The study highlights the multifactorial nature of cardiovascular health and disease prevention.
    • Further long-term studies are required to isolate the specific factors contributing to the apparent ASCVD protection in marathon runners.

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