Postoperative elevation in creatine kinase and its impact on renal function in patients undergoing complex partial...

Area of Science:

• Urology
• Nephrology
• Oncology

Background:

• Partial nephrectomy (PN) is a complex procedure for kidney tumor removal.
• Postoperative creatine kinase (CK) elevation is a potential complication.
• The impact of CK elevation on renal function post-PN requires further investigation.

Purpose of the Study:

• To identify risk factors for postoperative creatine kinase (CK) elevation following complex multifocal partial nephrectomy (PN).
• To assess the effect of elevated CK on renal function post-PN.

Main Methods:

• Retrospective analysis of patients undergoing PN between 2007-2012.
• Serum CK levels >2000 U/L defined as elevated.
• Renal function assessed via serum creatinine and estimated glomerular filtration rate (eGFR); regression analysis used to identify predictors.

Main Results:

• 42% of patients experienced CK elevation >2000 U/L.
• Younger age, higher BMI, and longer operating room time were associated with elevated CK.
• Elevated CK correlated with a greater immediate postoperative eGFR decline, but this effect resolved by 3 months.

Conclusions:

• Postoperative CK elevation is frequent after complex PN.
• Despite transient renal function decline, elevated CK does not independently impact long-term renal function post-PN.