Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensing Muscle Deformation for Upper-Limb Prosthetic Control: a Narrative Review.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same author

Use of RPNIs and Implanted Electrodes for Prosthetic Wrist and Multi-Grip Hand Control during Functional Tasks: A Case Study.

IEEE transactions on bio-medical engineering·2026
Same author

Regenerative Peripheral Nerve Interface and the Future of Intuitive Control.

Hand clinics·2026
Same author

Assessing Public Acceptability of AI-Integrated Preoperative Screening in Plastic Surgery.

Plastic and reconstructive surgery·2026
Same author

Effects of the Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 On Opioid Efficacy in Rat Neuropathic Pain States.

bioRxiv : the preprint server for biology·2026
Same author

HSR26-232: Disparities in ICU Utilization and Mortality in Tumor Lysis Syndrome: Evaluating Equity in Supportive Care Per NCCN Guidelines.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Related Experiment Video

Updated: Mar 22, 2026

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat
12:09

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat

Published on: April 18, 2020

13.2K

Comparative outcome measures in peripheral regeneration studies.

Stephen W P Kemp1, Paul S Cederna1, Rajiv Midha2

  • 1Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Michigan, Ann Arbor, MI, USA.

Experimental Neurology
|April 21, 2016
PubMed
Summary
This summary is machine-generated.

Selecting the right outcome measures is crucial for animal studies on nerve injury recovery. Different methods, like neuron counts or behavioral tests, offer varying insights into functional regeneration.

Keywords:
BehaviorFunctional recoveryNerveOutcome measuresRegeneration

More Related Videos

Maximum Isometric Tetanic Force Measurement of the Tibialis Anterior Muscle in the Rat
12:39

Maximum Isometric Tetanic Force Measurement of the Tibialis Anterior Muscle in the Rat

Published on: June 26, 2021

5.4K
Mouse Sciatic Nerve Transection/Resuture Procedure for Studying Nerve Repair and Functional Recovery
05:08

Mouse Sciatic Nerve Transection/Resuture Procedure for Studying Nerve Repair and Functional Recovery

Published on: January 16, 2026

126

Related Experiment Videos

Last Updated: Mar 22, 2026

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat
12:09

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat

Published on: April 18, 2020

13.2K
Maximum Isometric Tetanic Force Measurement of the Tibialis Anterior Muscle in the Rat
12:39

Maximum Isometric Tetanic Force Measurement of the Tibialis Anterior Muscle in the Rat

Published on: June 26, 2021

5.4K
Mouse Sciatic Nerve Transection/Resuture Procedure for Studying Nerve Repair and Functional Recovery
05:08

Mouse Sciatic Nerve Transection/Resuture Procedure for Studying Nerve Repair and Functional Recovery

Published on: January 16, 2026

126

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Experimental Surgery

Background:

  • Traumatic peripheral nerve injuries frequently cause paralysis, sensory loss, and chronic pain.
  • Animal models are essential for studying nerve injury and recovery, employing diverse assessment methods.
  • Choosing appropriate outcome measures is vital for accurate interpretation of experimental results.

Purpose of the Study:

  • To review and evaluate common outcome measures used in animal models of peripheral nerve injury.
  • To discuss the validity and sensitivity of different methods for assessing nerve regeneration and functional recovery.
  • To highlight potential discrepancies between outcome measures and provide guidance for selecting appropriate methods.

Main Methods:

  • Review of four primary categories of outcome measures: retrograde labeling, immunohistochemistry/histomorphometry, muscle reinnervation, and behavioral analysis.
  • Discussion of outcome measure validity across different nerve injury models (hindlimb, forelimb, facial).
  • Comparison of nerve crush, transection, and neuroma-in-continuity injury paradigms.

Main Results:

  • Certain outcome measures may be more sensitive to functional recovery than others.
  • Potential lack of association between different outcome measures can lead to inaccurate conclusions.
  • The severity of nerve injury influences the choice and interpretation of outcome measures.

Conclusions:

  • Researchers must carefully select outcome measures based on specific experimental interventions and scientific questions.
  • Awareness of the limitations and potential inaccuracies of different measures is essential for robust study design.
  • Appropriate selection of outcome measures ensures reliable assessment of nerve regeneration and functional recovery in animal models.