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Updated: Mar 22, 2026
Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
Published on: October 25, 2024
Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway
1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Tianjin Chinese Traditional Medicine University, No. 314, Anshan West Road, Nankai District, Tianjin, 300193, People's Republic of China. xiatian_tj@163.com.
Purpose:
The purpose of this study was to explore the molecular pathway of BSTCR (Bu Shen Tiao Chong recipe) in retrieving diminished ovary reserve (DOR).
Methods:
The DOR model was established through injecting cyclophosphamide and the effect of BSTCR was examined under this background.
Results:
BSTCR was shown to restore depleted brain-derived neurotrophic factor (BDNF), CDC2, cyclin B, GSH1, and P38 levels as well as impaired oocyte maturation and the higher apoptosis induced in DOR. BSTCR also enhances the response of oocytes to in vitro fertilization, with higher implantation rate, birth rate, and placenta weight.
Conclusion:
BSTCR might exert its beneficial role in oocyte maturation and restore DOR through regulating the BDNF pathway. And this pathway itself is probably through the consequence on several serum hormones such as FSH, E2, Inhibin B, etc.
