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Interleukin-12 serum level has prognostic value in patients with ST-segment elevation myocardial infarction
Mikhail V Zykov1, Olga L Barbarash2, Vasiliy V Kashtalap2
1Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation.
Objectives:
The study aimed to evaluate whether serum inflammatory markers have prognostic value in patients with ST-segment elevation myocardial infarction (STEMI).
Background:
The role of cytokine-driven inflammation in the development of postdischarge complications after STEMI is obscured.
Methods:
We recruited 214 patients who were admitted within 24 h of STEMI onset to our Institute. IL-1α, -6, -8, -10, -12, TNF-α, and CRP serum levels were measured on the 10-14th day after STEMI onset.
Results:
Serum levels of IL-12, TNF-α, and CRP were significantly higher in patients with 3 affected coronary arteries compared to those with 1 affected coronary artery. However, only Killip class II-IV at admission and IL-12 serum level ≥90.0 pg/mL were defined as statistically significant predictors of adverse outcome after 1 year of follow-up.
Conclusion:
IL-12 serum level may be suggested as a candidate prognostic marker if measured 10-14 days after STEMI onset.
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