Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

68.2K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
68.2K
Bacterial Signaling01:30

Bacterial Signaling

40.9K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.9K
Yeast Signaling01:28

Yeast Signaling

17.3K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.3K
What is Cell Signaling?02:03

What is Cell Signaling?

131.0K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
131.0K
Paracrine Signaling01:21

Paracrine Signaling

59.7K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
59.7K
Synaptic Signaling01:12

Synaptic Signaling

79.8K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
79.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SEMI-1, A Novel Neuronal Selenium-Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in C. elegans.

BioFactors (Oxford, England)·2026
Same author

<i>Bacillus</i><i>megaterium</i> DSM 32963 Enhances Specialized Pro-Resolving Mediator Production from an <i>n</i>-3 PUFA Salt in a Dynamic Model of the Human Intestine.

Metabolites·2025
Same author

Novel probiotic preparation with <i>in vivo</i> gluten-degrading activity and potential modulatory effects on the gut microbiota.

Microbiology spectrum·2024
Same author

Selective activation of cellular stress response pathways by fumaric acid esters.

FEBS open bio·2024
Same author

Correction: Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food.

Archives of toxicology·2024
Same author

Synbiotic <i>Bacillus megaterium</i> DSM 32963 and n-3 PUFA Salt Composition Elevates Pro-Resolving Lipid Mediator Levels in Healthy Subjects: A Randomized Controlled Study.

Nutrients·2024
Same journal

Targeting CD8+ T Cell-Derived Granzyme K Alleviates Radiation-Induced Pulmonary Fibrosis by Attenuating Senescence and SASP.

Archives of biochemistry and biophysics·2026
Same journal

The Binding Affinity and Recognition Specificity of Dopamine to Human Dopamine Receptors can be Rationally Altered by Halogen Doping.

Archives of biochemistry and biophysics·2026
Same journal

Cortical Cholesterol Deficit and Reduced Network Excitability in ApoE-Deficient Mice.

Archives of biochemistry and biophysics·2026
Same journal

Unraveling zinc's impact: Variable effects across concentrations in Phaseolus coccineus thylakoids.

Archives of biochemistry and biophysics·2026
Same journal

Characterizing tumor-associated endothelial cells in clear cell renal cell carcinoma via scRNA-seq and Bulk RNA-seq: construction of a prognostic risk signature.

Archives of biochemistry and biophysics·2026
Same journal

FOSB-Histone deacetylase 6 axis drives hepcidin-mediated ferroptosis in pulmonary ischemia-reperfusion injury.

Archives of biochemistry and biophysics·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Low-Cost Automated Flight Intercept Trap for the Temporal Sub-Sampling of Flying Insects Attracted to Artificial Light at Night
06:19

Low-Cost Automated Flight Intercept Trap for the Temporal Sub-Sampling of Flying Insects Attracted to Artificial Light at Night

Published on: December 29, 2021

3.1K

Peroxynitrite: From interception to signaling.

Bodo Speckmann1, Holger Steinbrenner2, Tilman Grune1

  • 1German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke, Department of Molecular Toxicology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.

Archives of Biochemistry and Biophysics
|April 21, 2016
PubMed
Summary
This summary is machine-generated.

Peroxynitrite, a reactive nitrogen species, causes oxidative damage. Selenoproteins and peroxiredoxins help reduce peroxynitrite, impacting protein function and cellular signaling pathways.

Keywords:
EbselenInsulin signalingPeroxynitrite reductaseProtein nitrationProteolysisSelenoproteins

More Related Videos

PARbars: Cheap, Easy to Build Ceptometers for Continuous Measurement of Light Interception in Plant Canopies
08:32

PARbars: Cheap, Easy to Build Ceptometers for Continuous Measurement of Light Interception in Plant Canopies

Published on: May 9, 2019

10.0K
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

29.6K

Related Experiment Videos

Last Updated: Feb 9, 2026

Low-Cost Automated Flight Intercept Trap for the Temporal Sub-Sampling of Flying Insects Attracted to Artificial Light at Night
06:19

Low-Cost Automated Flight Intercept Trap for the Temporal Sub-Sampling of Flying Insects Attracted to Artificial Light at Night

Published on: December 29, 2021

3.1K
PARbars: Cheap, Easy to Build Ceptometers for Continuous Measurement of Light Interception in Plant Canopies
08:32

PARbars: Cheap, Easy to Build Ceptometers for Continuous Measurement of Light Interception in Plant Canopies

Published on: May 9, 2019

10.0K
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

29.6K

Area of Science:

  • Biochemistry
  • Oxidative Stress
  • Cellular Signaling

Background:

  • Peroxynitrite is a potent oxidant and nitrating agent derived from superoxide and nitrogen monoxide.
  • It causes oxidative damage to proteins, leading to altered function, degradation, and modulated cellular processes.
  • This damage impacts protein turnover and cellular signaling cascades.

Purpose of the Study:

  • To review the biochemical interactions of selenocompounds and selenoproteins with peroxynitrite.
  • To explore peroxynitrite-induced modulation of cellular proteolysis.
  • To examine peroxynitrite-induced modulation of cellular signaling pathways.

Main Methods:

  • Literature review focusing on peroxynitrite biochemistry.
  • Analysis of studies on selenoprotein and peroxiredoxin interactions with peroxynitrite.
  • Examination of research on protein modification and degradation induced by peroxynitrite.

Main Results:

  • Selenoproteins, such as glutathione peroxidase-1 (GPx-1), and selenocompounds like ebselen, can scavenge peroxynitrite.
  • Peroxiredoxins also contribute to peroxynitrite reduction.
  • Peroxynitrite significantly modulates cellular proteolysis and signaling cascades.

Conclusions:

  • Selenocompounds and peroxiredoxins play crucial roles in mitigating peroxynitrite-induced damage.
  • Understanding these interactions is vital for comprehending cellular responses to oxidative stress.
  • Further research into peroxynitrite's role in cellular regulation is warranted.