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Anti-Yo Antibodies in Children With ADHD: First Results About Serum Cytokines

Renato Donfrancesco1, Paola Nativio2, Angela Di Benedetto1

  • 1Ospedale Sandro Pertini, Rome, Italy.

Journal of Attention Disorders
|April 21, 2016
PubMed

Insights

Attention-deficit/hyperactivity disorder (ADHD) children with anti-Yo antibodies showed higher levels of inflammatory cytokines, specifically Interleukin-6 (IL-6) and Interleukin-10 (IL-10). This suggests a link between immune system activity and ADHD.

Area of Science:

  • Neuroimmunology
  • Pediatric Neurology

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder.
  • The role of immune system dysregulation, including inflammation and autoantibodies, in ADHD is an emerging area of research.

Purpose of the Study:

  • To investigate the association between anti-Yo antibodies, pro-inflammatory activity, and serum cytokine levels in children with ADHD.
  • To compare cytokine profiles in ADHD children positive for anti-Yo antibodies versus healthy controls negative for these antibodies.

Main Methods:

  • A case-control study comparing 58 ADHD outpatients with 36 healthy children.
  • Measurement of serum levels for Interleukin-4 (IL-4), IL-6, IL-10, IL-17, tumor necrosis factor alpha (TNFα), and interferon gamma (IFNγ).
  • Testing for the presence of anti-Yo antibodies in both groups.

Main Results:

  • Anti-Yo antibodies were significantly more prevalent in the ADHD group (77.58%) compared to controls (22.42%).
  • ADHD children positive for anti-Yo antibodies exhibited significantly higher serum levels of IL-6 and IL-10 compared to controls.
  • No significant differences were reported for other tested cytokines.

Conclusions:

  • Immune system processes, particularly inflammation mediated by cytokines, are likely implicated in ADHD.
  • These findings contribute to understanding the interplay between neural antibodies, cytokines, and the pathophysiology of ADHD.

Keywords:
ADHDIL-10IL-6anti-Yocytokines

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