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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
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Impairment of Bony Crypt Development Associated With Hexavalent Chromium Exposure During Tooth Eruption
Luciana M Sánchez1, Marianela Lewicki2, Romina C De Lucca2
1Department of Histology and Embryology, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina. lucianamsanchez@hotmail.com.
Acta Odontologica Latinoamericana : AOL
|April 21, 2016
Summary
Hexavalent chromium exposure in infant rats delayed tooth eruption and reduced bone development. This highlights the critical need to control toxic substances in drinking water to protect children
Area of Science:
- Environmental Toxicology
- Developmental Biology
- Oral Biology
Background:
- Industrial wastes containing hexavalent chromium contaminate drinking water.
- Infants are vulnerable to toxic substances through breast milk or formula.
Purpose of the Study:
- To investigate the impact of hexavalent chromium on alveolar bone development and tooth eruption in suckling rats.
- To assess the effects of potassium dichromate intoxication on the developing mandible.
Main Methods:
- Wistar rats were administered potassium dichromate (12.5mg/kg) or saline daily for 10 days.
- Histologic and histomorphometric analyses of the mandible were conducted.
- Statistical analysis using Student's t test (p<0.05).
Main Results:
- Potassium dichromate exposure led to delayed tooth eruption.
- Significant decreases in periodontal width and alveolar bone volume were observed.
- Reduced bone formation surfaces and increased quiescent surfaces indicated impaired bone remodeling.
Conclusions:
- Hexavalent chromium exposure negatively affects alveolar bone remodeling, delaying tooth eruption.
- Controlling toxic substances in drinking water is crucial for normal growth and development in early infancy.
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