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Updated: Mar 22, 2026
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
Conformal radiotherapy as a bridge to liver transplantation for hepatocellular carcinoma: is it safe?
Kayvan Mohkam1,2, Nicolas Golse1, Mathieu Bonal1
1Department of General Surgery & Liver Transplant, Hospices Civils de Lyon, Croix-Rousse University Hospital, Lyon, France.
Aim:
To report a preliminary experience of conformal radiotherapy (CRT) as bridge to orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC).
Methods:
Data of 12 patients undergoing CRT for HCC followed by OLT between 2012 and 2014 were reviewed.
Results:
CRT was used in a neoadjuvant or downstaging setting in nine and three patients, respectively. No radiation-related systemic toxicity was observed. Median blood loss and operating time were 1450 ml (600-4000) and 420 min (240-510), respectively. Four patients had diaphragmatic injury. Complete histological response was observed in six patients, and partial response in five. Seven patients developed severe postoperative morbidity including five anastomosis-related complications and one death.
Conclusion:
CRT for HCC provides satisfactory histological response but may compromise OLT safety.
