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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

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Published on: October 3, 2010

Melanotic neuroectodermal tumor of infancy.

Xiao Wu¹, Samantha Shankar¹, William R Munday²

¹Department of Diagnostic Radiology, Yale School of Medicine, BOX 208042, Tompkins East 2, 333 Cedar Street, New Haven, CT 06520-8042, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|April 21, 2016

Summary

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare craniofacial tumor in infants. Imaging findings from CT and MRI can aid in preoperative diagnosis of this neural crest tumor.

Keywords:

CT scan Diagnostic imaging Infants Magnetic resonance Maxillary tumor Melanotic neuroectodermal tumor

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Area of Science:

Pediatric Oncology
Radiology
Pathology

Background:

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, pigmented craniofacial neoplasm.
This tumor originates from neural crest cells and typically affects newborns and infants.

Observation:

A case report details the imaging findings of a 3-month-old male infant with a maxillary MNTI.
The report includes detailed discussions of MNTI's appearance on various MRI sequences and CT scans.

Findings:

MNTI exhibits a characteristic radiographic appearance.
Histologically, it shows a biphasic cell population comprising melanin-containing cells and neuroblastic cells within a vascularized stroma.

Implications:

Accurate preoperative diagnosis of MNTI is possible using clinical findings, CT, and MRI.
Complete surgical excision is the primary treatment, with no recurrence noted at one-year follow-up in this case.