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Updated: Mar 22, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?

Mahdi Ghatreh-Samani1, Nafiseh Esmaeili2, Masoud Soleimani3

  • 1Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Central-European Journal of Immunology
|April 21, 2016
PubMed

Iron overload in β-thalassemia major occurs mainly due to blood transfusion, an essential treatment for β-thalassemia major patients, which results in oxidative stress. It has been thought that oxidative stress causes elevation of immune system senescent cells. Under this condition, cells normally enhance in aging, which is referred to as premature immunosenescence. Because there is no animal model for immunosenescence, most knowledge on the immunosenescence pattern is based on induction of immunosenescence. In this review, we describe iron overload and oxidative stress in β-thalassemia major patients and how they make these patients a suitable human model for immunosenescence. We also consider oxidative stress in some kinds of chronic virus infections, which induce changes in the immune system similar to β-thalassemia major. In conclusion, a therapeutic approach used to improve the immune system in such chronic virus diseases, may change the immunosenescence state and make life conditions better for β-thalassemia major patients.

Keywords:
antioxidant therapyiron overloadoxidative stressβ-thalassemia major

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