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Ensete superbum ameliorates renal dysfunction in experimental diabetes mellitus
1Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram-695581, Kerala, India.
Iranian Journal of Basic Medical Sciences
|April 21, 2016
Summary
Ensete superbum seed extract (ESSE) reduced blood glucose and HbA1c, improving kidney function in diabetic rats. This suggests ESSE
Area of Science:
- Pharmacology
- Nephrology
- Biochemistry
Background:
- Diabetic nephropathy is a significant complication of diabetes mellitus.
- Oxidative stress driven by hyperglycemia contributes to diabetic nephropathy pathogenesis.
Purpose of the Study:
- To investigate the protective effects of Ensete superbum seed extract (ESSE) on renal dysfunction.
- To evaluate the impact of ESSE on oxidative stress markers in a rat model of diabetes.
Main Methods:
- Streptozotocin-induced diabetic rats were treated with ESSE (400 mg/kg BW).
- Evaluated serum glucose, HbA1c, total protein, albumin, and renal function markers (urea, creatinine).
- Assessed lipid peroxidation, antioxidant enzymes, and performed renal histopathology.
Main Results:
- ESSE treatment significantly reduced glucose and HbA1c levels.
- Improved serum protein and albumin levels in diabetic rats.
- ESSE decreased renal function markers and lipid peroxidation, while increasing antioxidant levels, and ameliorated kidney damage.
Conclusions:
- Ensete superbum possesses antioxidant properties that protect against diabetic nephropathy.
- ESSE may delay or prevent the progression of diabetic kidney disease.
- The ethanolic extract of Ensete superbum seeds demonstrates potential therapeutic benefits for diabetes complications.
