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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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[Exercise Therapy for Children with Cancer Related Fatigue].

M Jung1, N Zepf1, B Fuchs1

  • 1Hochschule Fresenius gGmbH, School of Therapy & Social Work, Idstein.

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|April 21, 2016
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Cancer Related Fatigue (CRF) significantly impacts children undergoing cancer treatment. Exercise therapy shows promise for reducing CRF in pediatric oncology, but more research and better assessments are needed.

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Area of Science:

  • Pediatric Oncology
  • Exercise Therapy
  • Quality of Life

Background:

  • Cancer Related Fatigue (CRF) is a significant and debilitating side effect impacting children with cancer.
  • There is a notable lack of validated assessments and effective therapies for CRF in pediatric oncology.
  • Pediatric patients face challenges adapting to fatigue and reduced activity levels.

Purpose of the Study:

  • To systematically review existing literature on exercise therapy for Cancer Related Fatigue in pediatric oncology.
  • To identify the current state of research regarding CRF assessment and treatment in children.

Main Methods:

  • Systematic search of 4 databases for randomized controlled trials (RCTs), controlled clinical trials (CCTs), and clinical trials (CTs).
  • Analysis of systematic reviews focusing on exercise therapy in pediatric oncology.
  • Studies were evaluated using the PEDro Scale.

Main Results:

  • A limited number of studies (one RCT, two CCTs, one CT) were found addressing CRF reduction in pediatric oncology.
  • Intervention durations ranged from 2 days to 12 weeks, with variations in inpatient/outpatient settings and supervision.
  • Exercise therapy typically included strength and endurance training with warm-up and cool-down components.

Conclusions:

  • Exercise therapy shows potential for reducing Cancer Related Fatigue in pediatric oncology patients.
  • There is a critical need for developing improved assessment tools and conducting larger, individualized, supervised studies.
  • Underestimation and inadequate identification of CRF symptoms in pediatric oncology negatively affect patients' quality of life.