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Monocytes Take Their Own Path to IL-1β

Eric I Elliott1, Fayyaz S Sutterwala2

  • 1Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA; Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA.

Immunity
|April 21, 2016
PubMed
Summary

Researchers discovered a novel pathway for NLRP3 inflammasome activation in human monocytes. This alternative route triggers inflammasome activation with just a single stimulus, differing from the usual two-signal requirement.

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