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Getting the Skinny on CD4(+) T Cell Survival in Fatty Livers
Christopher M Walker1, Stanley M Lemon2
1Center for Vaccines and Immunity, Nationwide Children's Hospital and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH 43205, USA.
Immunity
|April 21, 2016
Abstract:
Non-alcoholic fatty liver disease is associated with hepatocellular carcinoma. In the March 10 issue of Nature, Greten and colleagues report that this metabolic disruption affects tumor surveillance by depleting CD4+ T helper cells through lipotoxic mechanisms associated with NAFLD.
