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Alteration of thiol-disulphide homeostasis in acute tonsillopharyngitis

Soner Sertan Kara1, Ozcan Erel2, Tugba Bedir Demirdag1

  • 1a Department of Pediatric Infectious Diseases , Gazi University Medical Faculty , Ankara , Turkey.

Redox Report : Communications in Free Radical Research
|April 21, 2016
PubMed

Insights

Thiol-disulphide homeostasis is altered in children with acute tonsillopharyngitis (AT). This disruption is more pronounced in viral AT than in bacterial AT, indicating a significant difference in thiol-disulphide balance.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Immunology

Background:

  • Thiol-disulphide homeostasis (TDH) plays a crucial role in cellular function and is implicated in various clinical conditions.
  • Alterations in TDH have been observed in different inflammatory and infectious diseases.

Purpose of the Study:

  • To investigate the association between thiol-disulphide homeostasis and acute tonsillopharyngitis (AT) in pediatric patients.
  • To compare TDH parameters in children with viral AT, bacterial AT, and healthy controls.

Main Methods:

  • The study included 94 children diagnosed with AT (73 viral, 21 bacterial) and 88 healthy control children.
  • Measurements of native thiol, total thiol, and disulphide levels were performed for all participants.

Main Results:

  • Children with both viral and bacterial AT exhibited significantly lower native and total thiol levels compared to healthy controls.
  • Disulphide levels were lower in bacterial AT than in viral AT, with viral AT showing significantly lower disulphide levels than controls.
  • Ratios of native/total thiol were reduced, while disulphide/native thiol and disulphide/total thiol ratios were elevated in AT patients, particularly in viral cases.
  • Correlations were observed between C-reactive protein (CRP) and white blood cell (WBC) counts with thiol and disulphide levels.

Conclusions:

  • Thiol-disulphide homeostasis is significantly altered in children suffering from acute tonsillopharyngitis.
  • The observed alterations in TDH are more pronounced in cases of viral tonsillopharyngitis compared to bacterial tonsillopharyngitis.
Abstract

Keywords:
Acute tonsillopharyngitisChildrenThiol-disulphide homeostasis

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