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Updated: Mar 22, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
Pain assessment during blood collection from sedated and mechanically ventilated children
Layra Viviane Rodrigues Pinto Dantas1, Thiago Silveira Pinto Dantas2, Valter Joviniano Santana Filho3
1Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Sergipe, Aracaju, SE, Brazil.
Insights
Painful procedures in pediatric intensive care units increase the Face, Legs, Activity, Cry and Consolability (FLACC) pain score and vital signs. Consistent pain assessment using FLACC and physiological monitoring is crucial for optimal pain management in critically ill children.
Area of Science:
- Pediatric Intensive Care
- Pain Management
- Critical Care Medicine
Background:
- Sedated and mechanically ventilated children in pediatric intensive care units (PICUs) require careful pain assessment.
- Routine procedures can cause pain, potentially impacting physiological stability.
Purpose of the Study:
- To assess pain and observe physiological parameters in sedated, mechanically ventilated children during a routine arterial blood gas collection.
- To evaluate the effectiveness of the Face, Legs, Activity, Cry and Consolability (FLACC) scale and physiological monitoring in this population.
Main Methods:
- An observational study was conducted in a PICU involving 35 children (1 month-12 years).
- Pain was assessed using the FLACC scale before, during, and after arterial blood gas collection.
- Physiological parameters including heart rate, respiratory rate, oxygen saturation, and blood pressure were recorded.
- Sedation levels were verified using the COMFORT-B scale.
Main Results:
- A statistically significant increase in FLACC scores (p = 0.0001) was observed during the painful procedure.
- Significant increases in heart rate (p = 0.03), respiratory rate (p = 0.001), and diastolic blood pressure (p = 0.006) were noted due to pain.
- These physiological changes indicate a pain response in sedated pediatric patients.
Conclusions:
- Standardized pain assessment using the FLACC scale is effective in identifying procedural pain in critically ill children.
- Monitoring physiological parameters alongside pain scores provides a comprehensive approach to pain evaluation.
- Consistent execution of pain and physiological assessments is recommended for optimizing pain management in PICUs.
Objective:
This study assessed pain and observed physiological parameters in sedated and mechanically ventilated children during a routine procedure.
Methods:
This observational study was performed in a pediatric intensive care unit. Thirty-five children between 1 month and 12 years of age were assessed before, during, and five minutes after an arterial blood collection for gas analysis (painful procedure). Face, Legs, Activity, Cry and Consolability scale was used to assess pain. In addition, patients' heart rate, respiratory rate, peripheral saturation of oxygen and blood pressure (diastolic and systolic) were recorded. COMFORT-B scale was applied before the pain and physiological parameter assessments to verify sedation level of the subjects.
Results:
There was an increase in Face, Legs, Activity, Cry and Consolability score (p = 0.0001) during painful stimuli. There was an increase in heart rate (p = 0.03), respiratory rate (p = 0.001) and diastolic blood pressure (p = 0.006) due to pain caused by the routine procedure.
Conclusions:
This study suggests that assessments of pain using standard scales, such as Face, Legs, Activity, Cry and Consolability score, and other physiological parameters should be consistently executed to optimize pain management in pediatric intensive care units.
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