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Iliac artery myointimal hyperplasia in rabbits submitted to angioplasty and treated with Moringa oleifera
Jânio Cipriano Rolim1, Manoel Ricardo Sena Nogueira1, Paulo Roberto da Silva Lima2
1Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Objective:
to assess post-angioplasty myointimal hyperplasia in iliac artery of rabbits treated with extract of Moringa oleifera leaves.
Methods:
we conducted a randomized trial in laboratory animals for five weeks of follow-up, developed in the Vivarium of Pharmaceutical Technology Laboratory of the Universidade Federal da Paraíba. We used rabbits from the New Zealand breed, subjected to a hypercholesterolemic diet and angioplasty of the external iliac artery, randomized into two groups: M200 Group (n=10) - rabbits treated with 200mg/kg/day of Moringa oleifera leaves extract orally; SF group (n=10) - rabbits treated with 0.9% saline orally. After five weeks, the animals were euthanized and the iliac arteries prepared for histology. Histological sections were analyzed by digital morphometry. Statistical analysis was performed using the Student's t test. The significance level was 0.05.
Results:
there was no significant difference in myointimal hyperplasia between M200 and SF groups when comparing the iliac arteries submitted to angioplasty.
Conclusion:
there was no difference of myointimal hyperplasia between groups treated with saline and Moringa oleifera after angioplasty.
