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Splicing-Mediated Autoregulation Modulates Rpl22p Expression in Saccharomyces cerevisiae

Jason Gabunilas1, Guillaume Chanfreau1,2

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, United States of America.

Plos Genetics
|April 21, 2016
PubMed
Summary

Rpl22p protein inhibits splicing of its own pre-mRNA (RPL22B) through a stem-loop structure. This autoregulatory mechanism fine-tunes Rpl22p levels based on cellular ribosome biogenesis needs.

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