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Identification of Circular RNAs using RNA Sequencing
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Circular RNA expression in basal cell carcinoma.

Michael Sand1,2, Falk G Bechara1, Daniel Sand3

  • 1Dermatologic Surgery Unit, Department of Dermatology, Venereology & Allergology, Ruhr-University Bochum, 44791 Bochum, Germany.

Epigenomics
|April 21, 2016
PubMed
Summary

This study identified differentially expressed circular RNAs (circRNAs) and their miRNA response elements (MREs) in basal cell carcinoma (BCC). These circRNAs may play a role in BCC development.

Keywords:
basal cell carcinomacircRNAscircular RNAnoncoding RNAs

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Area of Science:

  • Molecular Biology
  • Genomics
  • Dermatology

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs that regulate gene expression.
  • circRNAs can function as miRNA sponges through miRNA response elements (MREs).
  • Basal cell carcinoma (BCC) is a common skin cancer with complex molecular underpinnings.

Purpose of the Study:

  • To identify differentially expressed circRNAs in BCC.
  • To investigate the MREs within these circRNAs.
  • To explore the potential role of circRNAs in BCC pathogenesis.

Main Methods:

  • circRNA expression profiling using microarrays.
  • Quantitative reverse transcription PCR (qRT-PCR) for validation.
  • Bioinformatic analysis for MRE prediction and sequence analysis.

Main Results:

  • Identified 23 upregulated and 48 downregulated circRNAs in BCC.
  • Discovered 354 MREs within the differentially expressed circRNAs.
  • Demonstrated potential for these MREs to sequester BCC miRNomes.

Conclusions:

  • A distinct set of circRNAs are differentially expressed in BCC.
  • These circRNAs possess MREs that can interact with the BCC miRNome.
  • circRNAs are potentially involved in the molecular pathogenesis of BCC.