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Updated: Mar 22, 2026

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
Published on: March 25, 2016
Cutaneous Small/Medium CD4+ Pleomorphic T-Cell Lymphoma-Like Nodule in a Patient With Erythema Chronicum Migrans
Nil Celebi Cherukuri1, Christine G Roth, Nidhi Aggarwal
1*Department of Dermatology, University of Pittsburgh, Pittsburgh, PA; †Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA; ‡Division of Molecular and Genomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA; and §Pediatric Dermatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Abstract:
CD4+ small/medium pleomorphic T-cell lymphoma is a relatively rare subtype of cutaneous lymphoproliferative disorder with an indolent clinical behavior. The place of this condition among lymphomas is debatable. The authors describe a rare case of the direct association of CD4 small/medium pleomorphic T-cell lymphoma-like solitary nodule with Borrelia burgdorferi infection in a 5-year-old boy, discuss the reactive nature of this condition, and emphasize the importance of clinicopathological correlation.
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