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[Progress in researches on macrophages in liver fibrosis of schistosomiasis]
Abstract:
Schistosomiasis causes the imbalance of fibrogenesis and pro-fibrinolytic promoting factors, leading to extracellular matrix deposition and liver fibrosis. The activation of liver macrophages (Kupffer cells) and stellate cells are the two crucial events, which constitute a complex network regulating fibrosis balance. This review discusses the function of fibrotic cytokines secreted by macrophages, and their interaction and mutual influence with stellate cells in hepatic fibrosis. Additionally, the expected progress and novel in vitro and in vivo approaches that have been achieved recently in our laboratory are briefly introduced.
Insights
Schistosomiasis disrupts liver fibrosis balance by altering fibrogenesis and pro-fibrinolytic factors. Macrophage (Kupffer cell) and stellate cell interactions are key to understanding and treating hepatic fibrosis.
Area of Science:
- Immunology
- Hepatology
- Pathology
Context:
- Schistosomiasis-induced liver fibrosis results from dysregulated fibrogenesis and antifibrotic mechanisms.
- Hepatic fibrosis involves complex interactions between liver macrophages (Kupffer cells) and hepatic stellate cells.
- Understanding these cellular interactions is crucial for developing targeted therapies.
Purpose:
- To review the role of macrophage-secreted fibrotic cytokines in hepatic fibrosis.
- To elucidate the interaction network between Kupffer cells and stellate cells in regulating fibrosis.
- To introduce novel in vitro and in vivo approaches for studying hepatic fibrosis.
Summary:
- Schistosomiasis disrupts the balance of fibrogenesis and pro-fibrinolytic factors, leading to extracellular matrix deposition and liver fibrosis.
- The activation of Kupffer cells and stellate cells forms a complex regulatory network governing fibrosis.
- This review examines fibrotic cytokines from macrophages and their interplay with stellate cells, alongside recent laboratory advancements.
Impact:
- Provides a comprehensive overview of the cellular mechanisms driving schistosomiasis-related liver fibrosis.
- Highlights the critical roles of Kupffer cells and stellate cells in fibrotic processes.
- Introduces innovative research methodologies for investigating hepatic fibrosis and potential therapeutic strategies.
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