Related Experiment Video
Updated: Mar 22, 2026
11:10
Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
96.1K
Single Gallstone Associated with High Fasting Insulin Level.
Can Oner1, Sibel Yilmaz-Oner2, Ruhper Cekin3
1Department of Family Medicine, Dr. Lutfi Kirdar Kartal Education and Training Hospital, Istanbul, Turkey.
Summary
Hyperinsulinemia is linked to gallstones (GS). This study found a significant difference in insulin levels between patients with single versus multiple gallstones, though insulin did not correlate with stone size.
Area of Science:
- Endocrinology
- Gastroenterology
- Metabolic Syndrome
Background:
- Gallstone formation is multifactorial, with hyperinsulinemia identified as a contributing factor.
- Insulin resistance and elevated insulin levels are increasingly recognized in metabolic disorders.
Purpose of the Study:
- To investigate the association between gallstone characteristics (size and count) and insulin levels/resistance.
- To determine if insulin resistance correlates with gallstone burden.
Main Methods:
- Cross-sectional study of 84 patients with ultrasonographically confirmed gallstones.
- Measurement of serum insulin levels and calculation of insulin resistance using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index.
- Comparison of insulin parameters between patients with single versus multiple gallstones.
Main Results:
- 56.3% of patients exhibited insulin resistance.
- A non-significant correlation was observed between insulin levels and gallstone size (p=0.129).
- A significant difference in insulin levels was found between patients with single gallstones and those with multiple gallstones.
Conclusions:
- Insulin levels differ significantly based on gallstone count, suggesting a link between metabolic status and gallstone burden.
- While insulin resistance is prevalent, it does not appear to correlate with gallstone size in this cohort.
More Related Videos
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
72.4K
10:17An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
7.5K
Related Concept Videos
01:23Dipeptidyl Peptidase 4 Inhibitors
986
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
986
01:30Acute Pancreatitis II: Clinical Manifestations and Management
1.0K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.0K
01:05Insulin Secretory Vesicles
7.3K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
7.3K
01:15Diabetes: Symptoms, Diagnosis, and Complications
2.7K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.7K
01:16Hormones Regulating Blood Glucose
8.3K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
8.3K
01:15Hypoglycemia and Glucagon
1.3K
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.3K