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Is there any association between irritable bowel syndrome subgroups and autonomous dysfunction
A E Yildirim1, M Korkmaz, R Altun
1Department of Gastroenterology, Department of Internal Medicine, Başkent University, Faculty of Medicine, Ankara, Turkey. yildirimemrea@yahoo.com.
European Review for Medical and Pharmacological Sciences
|April 22, 2016
Summary
Autonomic dysfunction (AD) plays a role in irritable bowel syndrome (IBS) pathophysiology. IBS patients, particularly those with IBS-C, show more pronounced AD compared to healthy controls, suggesting a link to disease severity.
Area of Science:
- Gastroenterology
- Neurology
- Internal Medicine
Background:
- Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder.
- The brain-gut axis is crucial in IBS, but the role of autonomic dysfunction (AD) remains debated.
- Understanding AD's contribution to IBS pathophysiology is essential for improved management.
Purpose of the Study:
- To investigate and compare autonomic dysfunction in different irritable bowel syndrome subgroups.
- To assess the relationship between autonomic dysfunction and IBS characteristics.
Main Methods:
- Included 50 IBS patients and 49 healthy controls.
- Evaluated autonomic function using parasympathetic and sympathetic tests.
- Categorized patients into IBS subgroups (IBS-C, IBS-D).
Main Results:
- No demographic differences between IBS patients and controls.
- Significant differences in parasympathetic and sympathetic autonomic neuropathy tests were observed.
- IBS-C patients exhibited more severe parasympathetic dysfunction compared to IBS-D patients and controls.
- No correlation found between autonomic dysfunction severity and disease duration.
Conclusions:
- Autonomic dysfunction is implicated in the pathophysiology of irritable bowel syndrome.
- Deterioration of the autonomic system in IBS may affect multiple organ systems, including the cardiovascular system.
- Patients with IBS may face a broader range of health complications due to autonomic system impairment.
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