Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gluten-induced experimental IgA glomerulopathy.

R Coppo1, G Mazzucco, G Martina

  • 1Department of Biomedical Sciences, University of Turin, Italy.

Laboratory Investigation; a Journal of Technical Methods and Pathology
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality of life measures in Systemic Lupus Erythematosus: A systematic review.

Reumatismo·2022
Same author

Pregnancy success rate and response to heparins and/or aspirin differ in women with antiphospholipid antibodies according to their Global AntiphosPholipid Syndrome Score.

Seminars in arthritis and rheumatism·2020
Same author

Filling the gap in antiphospholipid syndrome diagnosis: a patient's story.

Lupus·2020
Same author

Safety of outpatient percutaneous native renal biopsy in systemic autoimmune diseases: results from a monocentric cohort.

Lupus·2018
Same author

The risk of ischaemic stroke in primary antiphospholipid syndrome patients: a prospective study.

European journal of neurology·2017
Same author

Percutaneous implant of Denver peritoneo-venous shunt for treatment of refractory ascites: a single center retrospective study.

European review for medical and pharmacological sciences·2017
Same journal

Changes in Three-Dimensional Intrahepatic Biliary Structures in Patients With Hepatobiliary Diseases Visualized Using Tissue-Clearing Methods.

Laboratory investigation; a journal of technical methods and pathology·2026
Same journal

Genome-wide SNP-based Profiling of Loss of Heterozygosity Reveals Distinct Molecular Subgroup-specific Patterns in Gastrointestinal Stromal Tumors (GIST).

Laboratory investigation; a journal of technical methods and pathology·2026
Same journal

AI-Assisted HER2 Scoring in Breast Cancer: Diagnostic Agreement and Understanding Discordance.

Laboratory investigation; a journal of technical methods and pathology·2026
Same journal

Corrigendum to "POU2F3 in Small Cell Lung Cancer (SCLC): Diagnostic Utility in Neuroendocrine-Low/Negative SCLC and Discrimination From Other Thoracic Malignancies and Other Small Blue Round Cell Tumors" [Laboratory Investigation 2026;106(6):106124].

Laboratory investigation; a journal of technical methods and pathology·2026
Same journal

Assessing the Effects of a 3D Pathology Tissue-Processing Workflow on Downstream Molecular Analyses.

Laboratory investigation; a journal of technical methods and pathology·2026
Same journal

Transcription Factor Ets-1 is a Central Regulator of Redox Balance and Liver Regeneration Through EGF and TGF-β1 Signaling.

Laboratory investigation; a journal of technical methods and pathology·2026
See all related articles

This study shows that gliadin, a component of gluten, triggers IgA immune deposits in the kidneys of BALB/c mice. These findings suggest a potential link between dietary gluten and kidney immune responses.

Area of Science:

  • Immunology
  • Nephrology
  • Gastroenterology

Background:

  • Dietary antigens can influence immune responses.
  • Gluten, a common dietary protein, has been implicated in various immune-mediated conditions.
  • The specific effects of gluten and its fraction, gliadin, on renal immune complex deposition require further elucidation.

Purpose of the Study:

  • To investigate the effect of alimentary gluten and gliadin in inducing immunoglobulin A (IgA) mesangial deposits in BALB/c mice.
  • To determine if gliadin administration leads to the formation of anti-gliadin IgA antibodies in circulation and renal tissue.
  • To compare the immune response in mice fed gluten-free diets versus those consuming gluten-containing diets.

Main Methods:

  • BALB/c mice were orally administered ovalbumin, human gamma-globulins, crude gluten, or gliadin.

Related Experiment Videos

  • Control groups included mice fed standard diets or gluten-free diets.
  • Renal IgA deposits were assessed using immunofluorescence, and anti-gliadin IgA antibodies were detected in serum and renal eluates.

    • Main Results:

    • Oral administration of gluten and gliadin significantly increased IgA mesangial deposits in mice compared to controls.
    • Anti-gliadin IgA antibodies were detected in circulation and renal tissue of mice fed gluten or gliadin.
    • Mice on a gluten-containing diet showed significantly higher IgA deposits and anti-gliadin IgA levels than gluten-free controls.

    Conclusions:

    • Gliadin, a fraction of gluten, demonstrably induces IgA immune deposits in the kidneys of BALB/c mice.
    • Dietary gluten intake is associated with increased renal IgA deposition and anti-gliadin IgA antibody production.
    • These findings highlight a potential mechanism by which dietary gluten may contribute to kidney pathology.