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Related Experiment Video

Updated: Mar 22, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

Kidney involvement in medium- and large-vessel vasculitis.

Federica Maritati¹, Francesco Iannuzzella², Maria P Pavia¹

¹Nephrology Unit, University Hospital, Parma, Italy.

Journal of Nephrology

|April 22, 2016

Summary

Medium- and large-vessel vasculitides (MVV and LVV) can significantly impact the kidneys, causing issues like renal artery stenosis and ischemia. Recognizing these renal manifestations is crucial for managing these inflammatory vascular diseases.

Keywords:

Giant-cell arteritis IgG4 Periaortitis Polyarteritis nodosa Renal artery stenosis Renal infarction Retroperitoneal fibrosis Takayasu arteritis

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Last Updated: Mar 22, 2026

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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Published on: June 16, 2014

Area of Science:

Vascular Inflammation
Nephrology
Rheumatology

Background:

Medium- and large-vessel vasculitides (MVV and LVV) are inflammatory disorders affecting major arteries.
This group includes giant-cell arteritis, Takayasu's arteritis, Kawasaki disease, and polyarteritis nodosa.
Chronic periaortitis may also be considered within this spectrum.

Purpose of the Study:

To review the renal involvement in MVV and LVV.
To highlight the importance of identifying renal abnormalities in these conditions.

Main Methods:

Literature review focusing on renal manifestations of MVV and LVV.

Main Results:

MVV and LVV primarily affect the aorta and its branches.
Unlike small-vessel vasculitides, they do not typically cause glomerulonephritis, but can lead to tubulo-interstitial nephritis.
Renal artery involvement is common, presenting as stenosis, intra-renal vasculitis, ischemia, infarction, microaneurysms, and hemorrhage.

Conclusions:

Renal artery and intra-renal vascular lesions are significant complications of MVV and LVV.
Renal abnormalities in these syndromes should not be overlooked during patient evaluation and management.