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Rota virus genotypes and the clinical severity of Diarrhoea among children under 5 years of age

Ezeonwu Bertilla Uzoma1, Chinedu Chukwubuikem, Efe Omoyibo

  • 1From the Department of Paediatrics, Federal Medical Centre, Asaba, Delta State, Nigeria.

The Nigerian Postgraduate Medical Journal
|April 22, 2016
PubMed

Insights

Rotavirus diarrhoea affects young children, with G12P[8] genotype linked to severe dehydration. This study identified common rotavirus serotypes and their impact on illness severity in Nigerian children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Diarrhoeal disease is a major cause of child mortality globally.
  • Rotavirus is a leading cause of severe diarrhoea in children under five.
  • Understanding rotavirus prevalence and serotypes is crucial for public health interventions.

Purpose of the Study:

  • To determine the prevalence and risk factors of rotavirus diarrhoea in children under five.
  • To identify common rotavirus serotypes and their association with diarrhoea severity.
  • To investigate the epidemiology of rotavirus in Asaba, Nigeria.

Main Methods:

  • A hospital-based cross-sectional study was conducted.
  • Stool samples from children under five with diarrhoea were tested for rotavirus antigen using ELISA.
  • Statistical analyses included t-tests and Chi-square tests.

Main Results:

  • Rotavirus was detected in 37.1% of the 132 children studied.
  • The most common genotypes were G3P[6] (24.5%), G1P[6] (12.2%), and G12P[8] (10.2%).
  • G12P[8] infection was associated with increased dehydration and overall diarrhoea severity.

Conclusions:

  • Rotavirus infection is prevalent in children under five with diarrhoea in Asaba.
  • The G12 rotavirus genotype, associated with severe outcomes, has emerged in the region.
  • Further surveillance and targeted interventions are needed to control rotavirus disease.
Abstract

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